英文名稱： Anti-RIOX1 rabbit polyclonal antibody
別 名： ribosomal oxygenase 1; ROX; NO66; JMJD9; MAPJD; UR
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： RIOX1
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
RIOX1 |
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Immunogen: |
Synthetic peptide of human RIOX1 |
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Full name: |
ribosomal oxygenase 1 |
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Synonyms: |
ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169 |
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SwissProt: |
Q9H6W3 |
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IHC positive control: |
Human thyroid cancer and Human ovarian cancer |
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IHC Recommend dilution: |
30-150 |
