中文名稱: 兔抗SMURF2多克隆抗體
英文名稱: Anti-SMURF2 rabbit polyclonal antibody
相關(guān)類別: 一抗
儲 存: 冷凍(-20℃)
宿 主: Rabbit
抗 原: SMURF2
反應(yīng)種屬: Human, Mouse
標 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術(shù)規(guī)格
Background: |
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. |
Applications: |
ELISA, IHC |
Name of antibody: |
SMURF2 |
Immunogen: |
Synthetic peptide of human SMURF2 |
Full name: |
SMAD specific E3 ubiquitin protein ligase 2 |
SwissProt: |
Q9HAU4 |
IHC positive control: |
Human gastric cancer and human liver cancer |
IHC Recommend dilution: |
25-100 |