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  • 產(chǎn)品名稱:兔抗RFFL多克隆抗體

  • 產(chǎn)品型號(hào):100ul
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價(jià)格:1560
  • 產(chǎn)品庫(kù)存:60
  • 產(chǎn)品文檔:
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兔抗RFFL多克隆抗體 公司擁有專業(yè)技術(shù)團(tuán)隊(duì),以科研**為宗旨,在生物試劑、科研耗材領(lǐng)域內(nèi)獨(dú)樹(shù)一幟,能為生命科學(xué)領(lǐng)域的廣大科研人員提供數(shù)萬(wàn)種抗體、數(shù)千種蛋白以及相關(guān)檢測(cè)試劑盒等。
詳情介紹:
中文名稱:兔抗RFFL多克隆抗體 

英文名稱: Anti-RFFL rabbit polyclonal antibody

別      名: CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN

相關(guān)類別: 一抗

儲(chǔ)      存: 冷凍(-20℃)

宿      主: Rabbit

抗      原: RFFL

反應(yīng)種屬: Human, Mouse, Rat

標(biāo) 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術(shù)規(guī)格

IHC Recommend dilution:

25-100

IHC positive control:

Human liver cancer

ELISA Recommended dilution:

2000-5000

SwissProt:

Q8WZ73

Synonyms:

CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN

Full name:

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

Immunogen:

Fusion protein of human RFFL

Name of antibody:

RFFL

Applications:

ELISA, IHC

Background:

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.


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