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  • 產(chǎn)品名稱:兔抗RING1多克隆抗體

  • 產(chǎn)品型號:100ul
  • 產(chǎn)品廠商:通蔚生物
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詳情介紹:
中文名稱:  兔抗RING1多克隆抗體  

英文名稱: Anti-RING1 rabbit polyclonal antibody

別      名: RNF1; RING1A

相關(guān)類別: 一抗

儲      存: 冷凍(-20℃) 避光

宿      主: Rabbit

抗      原: RING1

反應種屬: Human, Mouse, Rat

標 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術(shù)規(guī)格

Background:

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Applications:

WB

Name of antibody:

RING1

Immunogen:

Synthetic peptide of human RING1

Full name:

ring finger protein 1

Synonyms:

RNF1; RING1A

SwissProt:

Q06587

WB Predicted band size:

42 kDa

WB Positive control:

Hela cells

WB Recommended dilution:

500-1000



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