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  • 產(chǎn)品名稱：CPSF4抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
  • 產(chǎn)品文檔：
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詳情介紹：
中文名稱： CPSF4抗原（重組蛋白）

英文名稱： CPSF4 Antigen (Recombinant Protein)

別     名：  NAR; NEB1; CPSF30

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概     述：

Fusion protein corresponding to a region derived from 1-244 amino acids of human CPSF4

技術(shù)規(guī)格

Full name:

cleavage and polyadenylation specific factor 4, 30kDa

Synonyms:

NAR; NEB1; CPSF30

Swissprot:

O95639

Gene Accession:

BC003101

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs.





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