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  • 產(chǎn)品名稱：DOK4抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：
中文名稱： DOK4抗原（重組蛋白）

英文名稱： DOK4 Antigen (Recombinant Protein)

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述：

Fusion protein corresponding to a region derived from 7-237 amino acids of human DOK4

技術(shù)規(guī)格

Full name:

docking protein 4

Swissprot:

Q8TEW6

Gene Accession:

BC001540

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.






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